Paul M Stewart Selected Research

11-beta-Hydroxysteroid Dehydrogenase Type 1

3/2011	Cortisone-reductase deficiency associated with heterozygous mutations in 11beta-hydroxysteroid dehydrogenase type 1.
12/2010	Cerebrospinal fluid corticosteroid levels and cortisol metabolism in patients with idiopathic intracranial hypertension: a link between 11beta-HSD1 and intracranial pressure regulation?
12/2009	11Beta-hydroxysteroid dehydrogenase type 1 and its role in the hypothalamus-pituitary-adrenal axis, metabolic syndrome, and inflammation.
11/2009	11beta-hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle.
4/2009	Hepatic 11beta-HSD1 mRNA expression in fatty liver and nonalcoholic steatohepatitis.
1/2009	Selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 for patients with metabolic syndrome: is the target liver, fat, or both?
10/2008	Steroid biomarkers and genetic studies reveal inactivating mutations in hexose-6-phosphate dehydrogenase in patients with cortisone reductase deficiency.
10/2008	Impaired glucose tolerance and insulin resistance are associated with increased adipose 11beta-hydroxysteroid dehydrogenase type 1 expression and elevated hepatic 5alpha-reductase activity.
6/2008	Induction of hepatic 11beta-hydroxysteroid dehydrogenase type 1 in patients with alcoholic liver disease.
6/2008	Reduced glucocorticoid production rate, decreased 5alpha-reductase activity, and adipose tissue insulin sensitization after weight loss.

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Paul M Stewart Research Topics

Disease

26	Insulin Resistance 01/2022 - 09/2003
22	Obesity 10/2014 - 03/2002
21	Cushing Syndrome 01/2022 - 01/2002
21	Hypertension (High Blood Pressure) 01/2020 - 04/2002
13	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2016 - 09/2003
12	Inflammation (Inflammations) 01/2021 - 09/2005
10	Abdominal Obesity 01/2022 - 04/2002
9	Muscular Diseases (Myopathy) 01/2022 - 01/2002
9	Adrenal Insufficiency (Adrenal Gland Hypofunction) 10/2020 - 01/2006
9	Cortisone reductase deficiency 08/2011 - 08/2003
8	Osteoporosis 01/2022 - 06/2002
8	Neoplasms (Cancer) 01/2013 - 01/2003
8	Chronic Renal Insufficiency 03/2012 - 11/2008
6	Acromegaly 02/2014 - 09/2002
6	Type 2 Diabetes Mellitus (MODY) 08/2012 - 12/2005
6	Pituitary ACTH Hypersecretion 04/2012 - 01/2002
5	Birth Weight (Birth Weights) 11/2020 - 06/2003
5	Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal) 03/2014 - 08/2003
4	Metabolic Diseases (Metabolic Disease) 01/2022 - 01/2008
4	Pseudotumor Cerebri (Idiopathic Intracranial Hypertension) 01/2021 - 02/2010
4	Non-alcoholic Fatty Liver Disease 01/2016 - 04/2009
4	Hypopituitarism (Sheehan's Syndrome) 11/2015 - 03/2008
4	Arthritis (Polyarthritis) 05/2015 - 07/2012
4	Glucose Intolerance 06/2014 - 09/2002
4	Adenoma (Adenomas) 09/2013 - 04/2005
4	Essential Hypertension 01/2013 - 09/2003
4	Congenital Adrenal Hyperplasia (Hyperplasia, Congenital Adrenal) 06/2011 - 06/2004
4	Proteinuria 10/2010 - 08/2005
3	Overweight 01/2021 - 10/2014
3	Addison Disease (Addison's Disease) 01/2021 - 09/2006
3	Adrenal incidentaloma 12/2020 - 05/2008
3	Atrophy 01/2016 - 07/2013
3	Rheumatoid Arthritis 02/2015 - 01/2006
3	Diabetes Mellitus 10/2014 - 04/2003
3	Hypoglycemia (Reactive Hypoglycemia) 01/2011 - 12/2007
3	Hyperplasia 12/2010 - 04/2005
3	Weight Loss (Weight Reduction) 12/2010 - 06/2004
3	Albuminuria 10/2010 - 08/2005
3	Disorders of Sex Development (Intersexuality) 08/2007 - 06/2004
3	Hypokalemia 09/2006 - 06/2003
3	Breast Neoplasms (Breast Cancer) 04/2006 - 01/2003
2	Sarcopenia 01/2021 - 01/2017
2	Adrenal Cortex Neoplasms (Adrenocortical Cancer) 04/2017 - 01/2013
2	Vitamin D Deficiency 01/2017 - 07/2015
2	Body Weight (Weight, Body) 01/2016 - 07/2012
2	Sepsis (Septicemia) 07/2015 - 07/2006
2	Hyperinsulinism (Hyperinsulinemia) 06/2014 - 06/2008
2	Weight Gain 05/2014 - 12/2007
2	Hyperaldosteronism (Conn Syndrome) 09/2013 - 12/2010
2	Hypertrophy 09/2012 - 02/2007

Drug/Important Bio-Agent (IBA)

53	GlucocorticoidsIBA 01/2022 - 01/2002
42	Hydrocortisone (Cortisol)FDA LinkGeneric 01/2022 - 01/2002
31	11-beta-Hydroxysteroid Dehydrogenase Type 1IBA 03/2011 - 01/2002
18	EnzymesIBA 01/2020 - 01/2002
17	Oxidoreductases (Dehydrogenase)IBA 01/2020 - 09/2003
12	Glucose (Dextrose)FDA LinkGeneric 01/2021 - 09/2002
11	11-beta-Hydroxysteroid Dehydrogenase Type 2 (11 beta-Hydroxysteroid Dehydrogenase Type 2)IBA 06/2009 - 01/2002
10	AndrogensIBA 01/2021 - 08/2003
10	Adrenocorticotropic Hormone (ACTH)FDA Link 11/2015 - 01/2002
10	MineralocorticoidsIBA 10/2014 - 06/2003
10	Cortisone FDA Link 01/2012 - 01/2002
9	Messenger RNA (mRNA)IBA 01/2016 - 09/2004
8	Hormones (Hormone)IBA 01/2019 - 01/2003
8	SteroidsIBA 01/2019 - 06/2004
8	Insulin (Novolin)FDA Link 04/2013 - 11/2007
7	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2019 - 01/2002
7	galactose-6-phosphate dehydrogenaseIBA 10/2008 - 08/2003
6	Growth Hormone (Somatotropin)IBA 01/2022 - 04/2003
6	Biomarkers (Surrogate Marker)IBA 01/2021 - 01/2008
6	hydroxide ionIBA 07/2015 - 01/2003
6	AldosteroneIBA 09/2013 - 04/2005
6	Mineralocorticoid Receptors (Mineralocorticoid Receptor)IBA 03/2012 - 09/2003
6	SaltsIBA 06/2009 - 04/2002
5	Insulin-Like Growth Factor I (IGF-1)IBA 07/2015 - 05/2003
5	Spironolactone (Aldactone)FDA LinkGeneric 03/2012 - 08/2009
4	IodineIBA 01/2021 - 02/2019
4	LipidsIBA 01/2021 - 12/2007
4	Vitamin D FDA LinkGeneric 01/2017 - 05/2005
4	methylamphotericin B (AME)IBA 08/2010 - 08/2003
4	11-beta-Hydroxysteroid Dehydrogenases (11beta Hydroxysteroid Dehydrogenase)IBA 01/2010 - 08/2005
3	2- (1- (5- (cyclohexylcarbamoyl)- 6- propylsulfanylpyridin- 2- yl)- 3- piperidyl)acetic acidIBA 01/2022 - 01/2020
3	CreatinineIBA 01/2021 - 09/2005
3	Triglycerides (Triacylglycerol)IBA 01/2016 - 07/2012
3	Proteins (Proteins, Gene)FDA Link 10/2012 - 05/2005
3	CorticosteroneIBA 09/2012 - 12/2007
3	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 03/2012 - 08/2009
3	Calcitriol Receptors (Calcitriol Receptor)IBA 04/2006 - 09/2004
3	Co-Repressor ProteinsIBA 04/2006 - 01/2003
3	trichostatin A (A 300)IBA 04/2006 - 01/2003
3	theasinensin AIBA 04/2006 - 01/2003
3	SodiumIBA 08/2005 - 06/2003
3	IsoenzymesIBA 08/2005 - 09/2003
2	Prednisolone (Predate)FDA LinkGeneric 01/2020 - 04/2019
2	Mitotane (Lysodren)FDA Link 04/2017 - 01/2013
2	Steroid 11-beta-Hydroxylase (11 beta-Hydroxylase)IBA 09/2013 - 01/2013
2	Cytochrome P-450 CYP11B2 (CYP11B2)IBA 09/2013 - 01/2013
2	CollagenIBA 07/2013 - 11/2010
2	CytokinesIBA 10/2012 - 07/2012

Therapy/Procedure

16	Therapeutics 01/2021 - 09/2002
4	Radiotherapy 07/2014 - 03/2004